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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
5 mg | $70 | In Stock | |
10 mg | $113 | In Stock | |
25 mg | $243 | In Stock | |
50 mg | $413 | In Stock | |
100 mg | $618 | In Stock | |
500 mg | $1,330 | In Stock |
Description | BMY-14802 hydrochloride (BMS 181100 hydrochloride) is a selective antagonist of σ receptor (IC50 = 112 nM) with antipsychotic effects. BMY-14802 hydrochloride is an agonist of the α1-adrenergic receptor and 5-HT1A. |
Targets&IC50 | σ receptor:112 nM (IC50) |
In vitro | BMY-14802 hydrochloride shows effects on the firing of 5-HTergic and catecholaminergic neurons and affects behaviors in a 5-HT1A-sensitive manner[3]. |
In vivo | Intraperitoneal administration of BMY-14802 hydrochloride (5-20 mg/kg) shows anti-dyskinetic efficacy across a 4-fold dose range against L-DOPA-induced dyskinesias without affecting the efficacy of L-DOPA against lesion-induced akinesia. BMY-14802 hydrochloride reduces D1 and D2 receptor agonist-induced dyskinesias[2]. |
Alias | BMS 181100 hydrochloride, BMY-14802-1, BMY 14802 hydrochloride |
Molecular Weight | 384.85 |
Formula | C18H23ClF2N4O |
Cas No. | 105565-55-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | H2O: 9.0 mg/mL (23.4 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
H2O
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